What is Cagrilintide and how does it work?

Cagrilintide is a long-acting amylin analog that promotes feelings of fullness by slowing gastric emptying and signaling satiety to the brain. Unlike GLP-1 agonists, it mimics the hormone amylin released alongside insulin from pancreatic beta cells.

What is the recommended Cagrilintide dosing schedule?

Cagrilintide is typically started at 0.25mg weekly and titrated up every 4 weeks. Common titration steps are 0.25mg, 0.5mg, 1.2mg, and 2.4mg, with adjustments based on tolerability and weight loss response.

What are common Cagrilintide side effects?

Common side effects include nausea, diarrhea, constipation, and injection site reactions. These typically diminish over time and with slower dose titration. Serious side effects are rare but may include hypoglycemia when combined with insulin.

How does Cagrilintide differ from GLP-1 agonists?

While GLP-1 agonists target GLP-1 receptors, Cagrilintide works on amylin receptors, providing a complementary mechanism. This is why combining them (as in CagriSema) shows enhanced efficacy with up to 25% weight loss in clinical trials.

Precision Tool

Cagrilintide Dosage Calculator

Calculate the exact injection volume for your Cagrilintide dose. A long-acting amylin analog for weight management.

Input Values

Peptide Vial Size

Total peptide in your vial

Bacteriostatic Water

Amount of BAC water added

Desired Dose

Your target dose per injection

Results

Concentration

2.50 mg/mL

Volume to Inject

0.100 mL

Insulin Syringe

10.0 units

on a 100-unit (1mL) syringe

Total Doses Per Vial

20 doses

Draw to the 10.0 unit mark on your insulin syringe to get exactly 0.25mg of peptide.

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Clinical Dosing Guidelines

Product	Indication	Starting Dose	Max Dose
Cagrilintide	Weight Management	0.25mg weekly	2.4mg weekly

Titration Schedule

16+ weeks typical

Current Selection

Week 1-4 — 0.25mg

Titration schedules may vary. Always follow your clinician's guidance.

Cagrilintide is a long-acting amylin analog that promotes satiety.

Start with lower doses and titrate up every 4 weeks.

Inject once weekly subcutaneously.

Works through a different pathway than GLP-1 agonists.

Frequently Asked Questions

See all GLP-1 medications compared

Our comprehensive reference guide covers every GLP-1 agonist — from approved blockbusters like semaglutide to next-gen candidates in clinical trials. Compare efficacy, side effects, cost, and delivery routes.

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