What makes Mazdutide unique among weight loss peptides?

Mazdutide is a dual GLP-1/Glucagon receptor agonist that combines appetite suppression with enhanced energy expenditure. The glucagon component may help burn more fat, improve liver health, and provide metabolic benefits beyond pure GLP-1 agonists.

What is the recommended Mazdutide starting dose?

Clinical trials typically start at 3mg weekly, with gradual increases to 6mg or 9mg over several months. Titration helps minimize gastrointestinal side effects common to GLP-1 class agents.

How does the glucagon component in Mazdutide work?

Glucagon increases hepatic glucose production and stimulates fat oxidation, potentially leading to greater energy expenditure. This complements the appetite-suppressing effects of GLP-1 activation for enhanced weight loss.

What are Mazdutide side effects?

Common side effects mirror other GLP-1 agents: nausea, diarrhea, and vomiting. The glucagon component may cause slightly different blood sugar effects than pure GLP-1 agonists, but appears safe in clinical trials.

What is Mazdutide development status?

Mazdutide (IBI362) is being developed by Innovent Biologics in partnership with Eli Lilly. It is currently in Phase 3 clinical trials in China and other regions for obesity and type 2 diabetes.

Precision Tool

Mazdutide Dosage Calculator

Calculate the exact injection volume for your Mazdutide dose. A dual GLP-1/Glucagon receptor agonist for metabolic health.

Input Values

Peptide Vial Size

Total peptide in your vial

Bacteriostatic Water

Amount of BAC water added

Desired Dose

Your target dose per injection

Results

Concentration

5.00 mg/mL

Volume to Inject

0.600 mL

Insulin Syringe

60.0 units

on a 100-unit (1mL) syringe

Total Doses Per Vial

3 doses

Draw to the 60.0 unit mark on your insulin syringe to get exactly 3mg of peptide.

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Clinical Dosing Guidelines

Product	Indication	Starting Dose	Max Dose
Mazdutide (IBI362)	Obesity/T2D (Phase 3)	3mg weekly	9mg weekly

Titration Schedule

12+ weeks typical

Current Selection

Week 1-4 — 3mg

Titration schedules may vary. Always follow your clinician's guidance.

Mazdutide is a dual GLP-1/Glucagon receptor agonist.

Glucagon component may enhance fat oxidation and energy expenditure.

Inject once weekly subcutaneously.

Titrate slowly to minimize GI side effects.

Frequently Asked Questions

See all GLP-1 medications compared

Our comprehensive reference guide covers every GLP-1 agonist — from approved blockbusters like semaglutide to next-gen candidates in clinical trials. Compare efficacy, side effects, cost, and delivery routes.

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